Sigmar1 ELISA Kit for Mouse(Mus musculus) | EIAab.comSigmar1 ELISA Kit for Mouse(Mus musculus)

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Sigmar1 (Gene name),

Sigma non-opioid intracellular receptor 1 (Protein name ), SGMR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Sigmar1(Oprs1);

Protein name:

Sigma non-opioid intracellular receptor 1;

Alternative:

Sigma 1-type opioid receptor(Sigma1-receptor;Sigma1R);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with KCNA4 (By similarity). Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists.

Function:

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.

Subcellular Location:

Nucleus inner membrane Nucleus outer membrane Endoplasmic reticulum membrane Lipid droplet Cell junction Cell membrane Cell projection growth cone Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.

Protein Attributes:

Sequence length:

223

Sequence:

50:

100:

150:

200:

223:

YTLRAYARGL | RLELTTYLFG | QDS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:18391

String:

O55242

Pfam:

PF04622

UniGene:

Mm.425181

Uniprot:

O55242

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ELISA Kit for Mouse Sigma non-opioid intracellular receptor 1

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E5642h

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ELISA Kit for Mouse Sigma non-opioid intracellular receptor 1

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E5642r

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96T

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ELISA Kit for Mouse Sigma non-opioid intracellular receptor 1

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E5642b

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ELISA Kit for Mouse Sigma non-opioid intracellular receptor 1

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E5642c

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ELISA Kit for Mouse Sigma non-opioid intracellular receptor 1

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E5642m

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96T

CLIA Kit for Mouse Sigma non-opioid intracellular receptor 1

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U5642r

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96T

CLIA Kit for Mouse Sigma non-opioid intracellular receptor 1

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U5642h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Sigma non-opioid intracellular receptor 1

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U5642m

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MSDS:

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96T

CLIA Kit for Mouse Sigma non-opioid intracellular receptor 1

Cat.:

U5642c

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96T

CLIA Kit for Mouse Sigma non-opioid intracellular receptor 1

Cat.:

U5642b

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96T

Polyclonal Antibody for Mouse Sigma non-opioid intracellular receptor 1

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P5642Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Sigma non-opioid intracellular receptor 1

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P5642Rb-m

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Polyclonal Antibody for Mouse Sigma non-opioid intracellular receptor 1

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P5642Rb-r

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Monoclonal Antibody for Mouse Sigma non-opioid intracellular receptor 1

Protein for Mouse Sigma non-opioid intracellular receptor 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor."
Seth P. , Leibach F.H. , Ganapathy V.
Biochem. Biophys. Res. Commun.241:535-540(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);FUNCTION
strain: 129/Sv.
strain: C57BL/6.
tissue: Kidney.
2.

"Cloning and characterization of a mouse sigma1 receptor."
Pan Y.-X. , Mei J. , Xu J. , Wan B.-L. , Zuckerman A. , Pasternak G.W.
J. Neurochem.70:2279-2285(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
strain: C57BL/6.
tissue: Brain.
3.

Wang L.-M. , Shelness G.S. , Childers S.R. , Mach R.H. , Wheeler K.T.
Submitted (2000-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: C3H/HeJ.
tissue: Mammary gland.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
strain: NOD.
tissue: Dendritic cell.
tissue: Osteoclast.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: FVB/N.
tissue: Liver.
tissue: Mammary tumor.
6.

"Expression of the purported sigma(1) (sigma(1)) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy."
Kitaichi K. , Chabot J.-G. , Moebius F.F. , Flandorfer A. , Glossmann H. , Quirion R.
J. Chem. Neuroanat.20:375-387(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor."
Seth P. , Ganapathy M.E. , Conway S.J. , Bridges C.D. , Smith S.B. , Casellas P. , Ganapathy V.
Biochim. Biophys. Acta1540:59-67(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina."
Ola M.S. , Moore P. , El-Sherbeny A. , Roon P. , Agarwal N. , Sarthy V.P. , Casellas P. , Ganapathy V. , Smith S.B.
Brain Res. Mol. Brain Res.95:86-95(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
9.

"Regulating ankyrin dynamics: roles of sigma-1 receptors."
Hayashi T. , Su T.-P.
Proc. Natl. Acad. Sci. U.S.A.98:491-496(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ANK2 AND ITPR3;SUBCELLULAR LOCATION
10.

"Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice."
Langa F. , Codony X. , Tovar V. , Lavado A. , Gimenez E. , Cozar P. , Cantero M. , Dordal A. , Hernandez E. , Perez R. , Monroy X. , Zamanillo D. , Guitart X. , Montoliu L.
Eur. J. Neurosci.18:2188-2196(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
11.

"Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export."
Hayashi T. , Su T.-P.
J. Pharmacol. Exp. Ther.306:718-725(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"Involvement of kappa-opioid receptors and sigma receptors in memory function demonstrated using an antisense strategy."
Hiramatsu M. , Hoshino T.
Brain Res.1030:247-255(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Formalin-induced pain is reduced in sigma(1) receptor knockout mice."
Cendan C.M. , Pujalte J.M. , Portillo-Salido E. , Montoliu L. , Baeyens J.M.
Eur. J. Pharmacol.511:73-74(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine."
Kourrich S. , Hayashi T. , Chuang J.Y. , Tsai S.Y. , Su T.P. , Bonci A.
Cell152:236-247(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCNA2;FUNCTION

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